New mini litter Arrived in March!!!

Rovers Cove Toy & Mini Aussies: Puppies for sale in Washington
Rovers Cove Toy & Mini Aussies: Puppies for sale in Washington
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  • More
    • Home
    • Our Puppies
    • Available Adults
    • Applications & Deposits
    • Payment Plans
    • How Our Dogs Are Raised
    • About Us
    • A Rovers Cove Christmas
    • Rovers Cove Valentines
    • A Rovers Cove 4th of July
    • A Rovers Cove Tropicana
    • Health Concerns
    • Contact Us
    • Supplies
    • Health Guarantee
    • Our Dams
    • Our Sires
    • Our Bloodlines
    • Our Pups Grown Up
    • About Aussies
    • ASDR Breed Standard
    • Information Charts
    • English Angora Rabbits
    • Photography
    • HEALTH TESTING
  • Home
  • Our Puppies
  • Available Adults
  • Applications & Deposits
  • Payment Plans
  • How Our Dogs Are Raised
  • About Us
  • A Rovers Cove Christmas
  • Rovers Cove Valentines
  • A Rovers Cove 4th of July
  • A Rovers Cove Tropicana
  • Health Concerns
  • Contact Us
  • Supplies
  • Health Guarantee
  • Our Dams
  • Our Sires
  • Our Bloodlines
  • Our Pups Grown Up
  • About Aussies
  • ASDR Breed Standard
  • Information Charts
  • English Angora Rabbits
  • Photography
  • HEALTH TESTING

HEALTH CONCERNS

WHEN SHOULD YOU SPAY & NEUTER?

Risks of Early Spaying and Neutering

Please Watch this Informative Video by Dr. Karen Becker

In recent years the scientific studies have changed how veterinarians view spaying and neutering.

Is sterilization better than traditional spaying and neutering? And what is the correct time frame?

https://youtu.be/enPCZA1WFKY

Learn More

https://youtu.be/enPCZA1WFKY

Find out more

MDR1 and Genetics

MDR1 Facts and Myths

 MDR1 is a dominant gene .


1 copy = moderately affected 

2 copies = strongly affected 


Many Drugs are known to cause neurological signs related to the MDR1 mutation. 

These are among the worst:

Acepromazine, butorphanol, doxorubicin, emodepside, erythromycin, ivermectin, loperamide, milbemycin, moxidectin, rifampin, selamectin, vinblastine and vincristine. 


The MDR1 gene mutation can be fatal when affected Aussies are exposed to medications like Trifexis and Ivermectin for dogs (among many other medications).


MDR stands for multi-drug resistance and the mutation in the MDR1 gene prevents many breeds, including Australian Shepherds, from removing  many drugs from the brain resulting in toxicity. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. Dogs with the MDR1 mutation can be 200 times more sensitive to the drugs than dogs that do not have this mutation.

Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. When this process is interrupted the drugs build up and permeate the brain and neurological toxicity results.


Just because a dog tests negative does not mean it's safe.


All herding dogs, even those tested and cleared for the MDR1 gene mutation, can be at risk. How? The same problem caused by the MDR1 mutation can be triggered by several medications. The effect of the drugs may result in the same toxicity in healthy dogs as would occur with dogs who have tested positive for the MDR1 mutation. Of course, these drugs would affect dogs that have been cleared, those that are carriers, and those that are affected. So, no dog is completely safe.

So instead of the normal P-glycoprotein pumps not working because of the MDR1 mutation they are deactivated by the drugs. Either way the effect of neurotoxicity is the same.


The MDR1 Chart above shows the drugs broken down by the degree of risk they pose. This is not a complete list.

Im addition, grapefruit juice or extract should be avoided.

Learn More

For more information see

https://www.australian-shepherd-lovers.com/ivermectin-for-dogs.html

Find out more


  • Home
  • Our Puppies
  • Available Adults
  • Applications & Deposits
  • How Our Dogs Are Raised
  • About Us
  • A Rovers Cove Christmas
  • Rovers Cove Valentines
  • A Rovers Cove 4th of July
  • Health Concerns
  • Contact Us
  • Supplies
  • Health Guarantee
  • Our Dams
  • Our Sires
  • Our Bloodlines
  • Our Pups Grown Up
  • About Aussies
  • ASDR Breed Standard
  • Information Charts
  • English Angora Rabbits
  • Photography
  • HEALTH TESTING

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